Thanks for the links/tips, I got AmiKitX working again by following all the steps to manually remove wine / xquartz files.
I have backed up amikitx app like you suggested.
So AmiKitX boots and works
BUT the first time (after fresh new install) I start AmiKitX, I still get this error "program not responding" and ONLY after Quitting AmiKitX, then Wine will load (Wine says it is is updating) and Launch window is then loaded and I can boot into AmiKitx.
So I got it to work with your help, but I still get the error sometimes, and that is what I dont understand ...